Publications

Full list on Google Scholar

Journal Articles

• Gene-based recessive diplotype analysis identifies FGF6 in iron metabolism and hemochromatosis
  Published in Blood, 2019

  A novel gene-based recessive diplotype approach applied to the Marshfield PMRP exome-chip cohort identified FGF6 as a new iron-metabolism gene associated with hemochromatosis.

  Guo S, et al. (2019). "A gene-based recessive diplotype exome scan discovers FGF6, a novel hepcidin-regulating iron-metabolism gene." Blood, 133(17):1888-1898.

  Paper Code
• Identification of methylation haplotype blocks for tissue-of-origin mapping from plasma DNA
  Published in Nature Genetics, 2017

  Defined methylation haplotype blocks across the human genome and used cell-free circulating DNA methylation to non-invasively map tissue-of-origin and detect tumor signals.

  Guo S, et al. (2017). "Identification of methylation haplotype blocks aids in deconvolution of heterogeneous tissue samples and tumor tissue-of-origin mapping from plasma DNA." Nature Genetics, 49(4):635-642.

  Paper
• The DNA methylome of human peripheral blood mononuclear cells
  Published in PLoS Biology, 2010

  A reference whole-genome bisulfite methylome of human peripheral blood mononuclear cells, an early landmark in human epigenome characterization.

  Li Y, Zhu J, Tian G, ... Guo S, et al. (2010). "The DNA methylome of human peripheral blood mononuclear cells." PLoS Biology, 8(11):e1000533.

  Paper
• Single-base resolution methylomes of the silkworm reveal a sparse epigenomic map
  Published in Nature Biotechnology, 2010

  Generated the first single-base-resolution DNA methylome of an invertebrate, characterizing the sparse and gene-body-enriched methylation landscape of the silkworm.

  Xiang H, Zhu J, Chen Q, ... Guo S, et al. (2010). "Single base-resolution methylome of the silkworm reveals a sparse epigenomic map." Nature Biotechnology, 28(5):516-520.

  Paper