Novel 2019 coronavirus genome in Wuhan, China and USA

23 January 2020
  • Janssen Vaccine start phase 1/2 clinical trials……..
  • SARS-CoV (accession no. NC_004718): https://www.ncbi.nlm.nih.gov/nuccore/NC_004718.3?report=fasta
  • Virus variants reflect patients severity: https://www.medrxiv.org/content/10.1101/2020.04.14.20060160v1.full.pdf+html
  • 04/13/2020: xxx whole genome of COV19 were downloaded and you can download here
  • 04/12/2020: Effective reproductive number (R) decrease from 3.0 to 0.3 with cordons sanitaire, traffic restriction, social distancing, home confinement, centralized quarantine, and universal symptom survey.
  • 04/05/2020: The COVID-19 host genetics initiative: https://covid19hg.netlify.com/
  • 04/05/2020: SITC Statement on anti-IL-6/IL-6R for COVID-19, use of IL-6 or IL-6-receptor (IL-6R) blocking antibodies like tocilizumab (Actemra, Roche-Genentech), sarilumab (Kevzara, Regeneron) and siltuximab (Sylvant, EUSA Pharma)
  • 04/01/2020: How The Body Reacts To Viruses from Harvard University video
  • 03/30/2020: Susceptibility of ferrets, cats, dogs, and different domestic animals to SARS-coronavirus-2
  • 03/30/2020: Janssen works together with Harvard using Janssen patented technique: AdVac and PER.C6 to develop COVID19 vaccines.
  • 03/30/2020: Janssen and Biomedical Advanced Research and Development Authority (BARDA) for 1 billion $ Vaccines development
  • 03/12/2020: ACE2 and TMPRSS2: The novel coronavirus 2019 (2019-nCoV) uses ACE2 and TMPRSS2 to entry target cells
  • 03/06/2020：Covid-19 Small Molecule Therapies Reviewed from Science Translational Medicine
  • 03/07/2020: FTF to download Virus Genome: ftp://download.big.ac.cn/Genome/Viruses/Coronaviridae/genome/
  • 03/07/2020: Virus Genome Download Update: https://bigd.big.ac.cn/ncov/release_genome and https://www.gisaid.org/
  • 03/03/2020: How is AI Informing the Global Health and Business Response to 2019-nCOV?
  • 03/03/2020: Technical Problems with Existing CDC COVID-19 Primers, and an Improved Set of Primers.
  • 02/03/2020: Dr. Zheng-Li Shi published A pneumonia outbreak associated with a new coronavirus of probable bat origin in Nature.
  • 02/03/2020: Dr. Yong-Zhen Zhang lab in IBS,Fudan University published A new coronavirus associated with human respiratory disease in China in Nature
  • 02/03/2020: demographics, clinical information and reason of infection were available for the first 2020 patents, click here to download
  • 02/02/2020: 54 nCoV RNAs are available: https://raw.githubusercontent.com/Shicheng-Guo/2019nCoV/master/2019_nCov_genomes_2020.02.02.fasta
  • 01/30/2020: Kaggle online: Daily level information on the number of 2019-nCoV affected cases across the globe:
  • 01/25/2020: German Prof. Rolf Hilgenfeld, structure biologist, bring his coronavirus Substances of inhibitors to Wuhan to test the efficacy, see nature news.
  • 01/24/2020: Host and infectivity prediction of Wuhan 2019 novel coronavirus using deep learning algorithm
  • 01/23/2020: Discovery of a novel coronavirus associated with the recent pneumonia outbreak in 3 humans and its potential bat origin
  • 01/19/2020: A mathematical model for simulating the transmission of Wuhan novel Coronavirus, see bioRxiv
  • 01/24/2020: One way that viruses adapt is by encoding proteins using the same choice of codons as their host??
  • 01/24/2020: primary host -> intermediate host -> human, secondary host require long time to accumulate mutation
  • 01/24/2020: more discussion about 2019-nCoV in virological: http://virological.org/t/novel-2019-coronavirus-genome/319
  • 01/24/2020: one-off Nextstrain build for SARS-like coronaviruses from Bedford Lab: https://github.com/blab/sars-like-cov
  • 01/24/2020: ACE2 and TMPRSS2: Angiotensin I Converting Enzyme 2, functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63.
  • 01/23/2020: Phylogeny of 6 SARS-like betacoronaviruses in Wuhan.
  • Phylogeny
  • 01/23/2020: Five new genomes have been deposited in the GISAID platform: https://gisaid.org/CoV2020
  • 01/23/2020: USA confirmed the first 2019-nCoV occurred in USA in the state of Washington
  • 01/23/2020: Upload fasta file to 2019nCoV and compared with other nCoV
  • 01/22/2020: Dr. Shi identified bat as the virus host and upload the paper to bioRxiv
  • 01/10/2020: Fudan University shared the sequence to GenBank with accession MN908947
  • 12/12/2019: the first 2019-nCoV occurred in Wuhan, China and scientist think the earliest time might be 11/20/2019
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